betway必威登陆网址 (betway.com )学报››2023,Vol. 44››Issue (6): 430-436.DOI:10.3969/j.issn.2097-0005.2023.06.006

• 公共卫生与预防医学 •上一篇下一篇

1990—2019年中国抑郁症发病趋势的Joinpoint回归与年龄‐时期‐队列分析

郭浩阳1(), 汪伟1, 季新灿1, 陶梦君2, 袁慧1()

  1. 1.皖南医学院公共卫生学院,安徽 芜湖 241000
    2.皖南医学院第一附属医院健康管理中心,安徽 芜湖 241000
  • 收稿日期:2023-01-09出版日期:2023-06-25发布日期:2023-07-11
  • 通讯作者:袁慧
  • 作者简介:郭浩阳,硕士研究生,研究方向:慢性非传染性疾病的流行病学, E-mail:1961909010@qq.com
  • 基金资助:
    皖南医学院中青年科研基金(WKS2022F03)

Joinpoint regression and age-period-cohort analysis of the incidence trends of depression in China from 1990 to 2019

Haoyang GUO1(), Wei WANG1, Xincan JI1, Mengjun TAO2, Hui YUAN1()

  1. 1.School of Public Health,Wannan Medical College,Wuhu 241000,China
    2.Health Management Center,the First Affiliated Hospital of Wannan Medical College,Wuhu 241000,China
  • Received:2023-01-09Online:2023-06-25Published:2023-07-11
  • Contact:Hui YUAN

摘要:

目的分析1990—2019年中国抑郁症的发病趋势及年龄、时期和队列效应产生的影响。方法整理全球疾病负担研究2019(global burden of disease study 2019, GBD 2019)数据库中1990—2019年中国10 ~ 94岁人群抑郁症发病率数据,利用Joinpoint回归模型对抑郁症标化发病率的时间趋势进行分析;运用年龄‐时期‐队列模型分析抑郁症的年龄、时期和队列效应。结果1990—2019年中国居民抑郁症的标化发病率总体呈下降趋势,女性高于男性,存在性别差异。Joinpoint回归模型显示,女性抑郁症标化发病率在1990—2019年平均每年下降0.64%[平均年度变化百分比(average annual percent change, AAPC) = -0.64%,P< 0.001)];男性抑郁症标化发病率在1990—2019年平均每年下降0.26%(AAPC = -0.26%,P= 0.008)。年龄‐时期‐队列模型显示,抑郁症发病风险总体随年龄的增加而上升;随时期的推移变化趋势不明显;随队列的推移总体为下降趋势。结论1990—2019年中国居民抑郁症的标化发病率总体呈下降趋势,应关注老年人群,制定卫生政策,以减轻社会负担及促进老年人群的心理健康。

关键词:抑郁症,发病率,Joinpoint回归,年龄‐时期‐队列模型

Abstract:

ObjectiveTo analyze the trends of depression in China from 1990 to 2019 and the impact resulting from age, period, and cohort effects.MethodsData on the incidence rate of depression among Chinese aged 10~94 years from 1990 to 2019 in the Global Burden of Disease (GBD) Study 2019 database were collated to analyze the time trend of depression standardized incidence rate using Joinpoint regression model; Age-period-cohort models were used to analyze the age, period, and cohort effects of depression.ResultsThe standardized incidence rate of depression among Chinese residents showed a decreasing trend from 1990 to 2019, and was higher in women than in men, with a gender difference. Joinpoint regression models showed that the standardized incidence rate of depression among women decreased by an average of 0.64% per year from 1990 to 2019 (AAPC = -0.64%,P< 0.001); the male depression standardized incidence rate decreased by an average of 0.26% per year from 1990 to 2019 (AAPC = -0.26%,P= 0.008). Age-period-cohort models showed that the overall risk of depression increased with age; The trend of change with the increase of period was not significant; there was an overall decreasing trend with the increase of birth cohort.ConclusionThe standardized incidence rate of depression among Chinese residents shows a decreasing trend from 1990 to 2019, and the focus should be on the elderly population and health policies should be developed to reduce the social burden and promote the mental health of the elderly population.

Key words:depression,incidence rate,Joinpoint regression,age-period-cohort model