铁基磁性纳米载体在肿瘤治疗中的应用

betway必威登陆网址（betway.com ）学报››2021,Vol. 42››Issue (5): 333-339.DOI:10.3969/j.issn.2097-0005.2021.05.003

铁基磁性纳米载体在肿瘤治疗中的应用

牛盼红¹, 王岩¹, 刘营营¹, 张洁¹, 张书平^1,2, 刘思金³

betway必威登陆网址 (betway.com ) 1.生物医学科学学院;
2.医学科技创新中心,山东济南 250062;
3.中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京 100085

收稿日期:2021-03-15出版日期:2021-05-25发布日期:2021-08-31
通讯作者:张书平,E-mail:spzhang@sdfmu.edu.cn。
作者简介:牛盼红,副教授,博士,研究方向:铁死亡驱动纳米治疗和炎症疾病靶向治疗。刘思金,中国科学院遗传与发育生物学研究所博士,美国麻省理工学院和美国哈佛大学医学院附属儿童医院博士后,研究员,国家杰出青年基金获得者,中科院百人计划入选者,万人计划入选者,国家973项目首席科学家。主持国家自然基金面上项目2项,中国科学院知识创新工程重要方向项目1项,中国科学院“百人计划”项目1项。研究方向:环境毒理与健康、纳米材料和颗粒物的安全性与转化毒理,已发表SCI学术论文150余篇。研究成果先后在国际著名期刊上发表,部分研究成果被Nature、Science Daily等学术期刊多次报道和评述。张书平,betway必威登陆网址特聘教授,泰山学者青年专家。主要研究铁代谢紊乱诱导的造血障碍、癌症等疾病的发生发展以及铁死亡介导的相关分子机制,并探索相应的纳米治疗;同时关注环境污染等外界风险因素对铁代谢和疾病进程的影响。近5年共发表相关SCI论文30余篇,包括以第一或通讯作者发表在Blood、Advanced Science、eLife、ACS Nano、Journal of Hazardous Materials等权威期刊上;参与专著编撰一部;主持和参与多项国家自然科学基金、国家973等项目。
基金资助:
国家自然科学资金(22076104);betway必威登陆网址 “科教融合人才引进”项目。

Application of iron-based magnetic nanocarriers in tumor therapy

Niu Panhong¹, Wang Yan¹, Liu Yingying¹, Zhang Jie¹, Zhang Shuping^1,2, Liu Sijin³

1. Academy of Medical Sciences;
2. Medical Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, China;
3. State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences, Beijing 100085, China

Received:2021-03-15Online:2021-05-25Published:2021-08-31

摘要/Abstract

摘要：纳米载药在肿瘤治疗中所取得的进展推动了纳米材料在生物医学方向的发展,其中,铁基磁性纳米材料因其良好的磁学、优异的生物兼容性以及表面易于功能化修饰等优势,作为纳米载体在肿瘤治疗中得到了广泛关注和快速发展。虽然目前对Fe₃O₄磁性纳米载体有了系统性的了解,但对作为纳米载体的铁基磁性纳米粒子的全面、系统认识仍有待加强。随着肿瘤纳米递药系统设计的快速发展,亟需对铁基磁性纳米载体的制备过程和作用机理进行系统性的梳理。此外,铁死亡作为一种新型细胞死亡方式,其在肿瘤等慢性疾病的发生发展过程中的作用正逐步被重视,而铁基磁性纳米粒子在肿瘤治疗应用中对铁死亡产生怎样的影响,仍有待阐明。本综述系统介绍了铁基磁性纳米载药平台的发展、种类和制备方法,并详细总结了铁基磁性纳米粒子在肿瘤诊疗一体化中的应用,包括磁场辅助靶向、磁共振成像、磁热治疗等方面,同时对其参与Fenton反应引发铁死亡的相关机理进行了阐述。

关键词:纳米载药,铁基磁性纳米载体,肿瘤,铁死亡

Abstract:Nano-drug delivery for tumor therapy has promoted the development of nanomaterials in the realm of biomedicine. Among them, iron-based magnetic nanomaterials have the advantages of good magnetism, excellent biocompatibility, and easy functional modification of the surface. As a nanocarrier, iron-based magnetic nanomaterials have received extensive attention and achieved rapid development in tumor therapy. Although there is a systematic understanding of Fe₃O₄magnetic nanocarriers, the comprehensive and systematic understanding of iron-based magnetic nanoparticles carriers still needs to be strengthened. With the rapid development of tumor nano-drug delivery system design, it is urgent to systematically review the preparation process and mechanism of iron-based magnetic nanocarriers. In addition, ferroptosis, as a new type of cell death, receives much more attention in the role of occurrence and development of tumors and other chronic diseases, and the effect of iron-based magnetic nanoparticles on ferroptosis in tumor treatment applications remains to be elucidated. This review systematically introduces the development, types and preparation methods of iron-based magnetic nanometer drug-loading platforms, and detailedly summarizes the application of iron-based magnetic nanoparticles in the integration of tumor diagnosis and treatment, including magnetic field-assisted targeting, magnetic resonance imaging, and magnetocaloric therapy , and the mechanism of ferroptosis caused by the Fenton reaction is also iilustrated.

Key words:nano-drug delivery,iron-based magnetic nanocarriers,tumor,ferroptosis

中图分类号:

R730.5

牛盼红, 王岩, 刘营营, 张洁, 张书平, 刘思金. 铁基磁性纳米载体在肿瘤治疗中的应用[J]. betway必威登陆网址（betway.com ）学报, 2021, 42(5): 333-339.

Niu Panhong, Wang Yan, Liu Yingying, Zhang Jie, Zhang Shuping, Liu Sijin. Application of iron-based magnetic nanocarriers in tumor therapy[J]. Journal of Shandong First Medical Unversity & Shandong Academy of Medical Sciences, 2021, 42(5): 333-339.

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