关键词:门静脉血栓,生物学标志物,炎症,肝硬化,预测价值

Abstract:

Portal vein thrombosis （PVT） is a thrombosis in the main portal vein and branches of the portal vein within the liver， with or without mesenteric and splenic vein involvement， characterized by partial or complete occlusion of the portal vein. It is a common and serious complication in patients with cirrhosis， and its incidence is positively correlated with the severity of cirrhosis and portal hypertension. Portal vein thrombosis can worsen liver function in cirrhotic patients， exacerbate portal hypertension and lead to variceal bleeding associated with portal hypertension， which may increase the risk of acute cirrhotic failure， and it can also make liver transplantation more difficult and reduce the survival rate of the recipient， making early detection and prevention of PVT particularly important. However， as PVT often has an insidious onset and there are usually no obvious clinical symptoms in the early stages， it is difficult to diagnose PVT based on the clinical presentation； therefore， it is crucial to study serological indicators reflecting potential thrombosis， as all venous thrombosis is multifactorial due to the components of the Virchow triad： hypercoagulable state， endothelial damage and reduced blood flow. This article provides a review of recent studies on risk factors for PVT formation and serological indicators for early prediction.

Key words:portal vein thrombosis,biological markers,inflammation,cirrhosis,predictive value