关键词:质子泵抑制剂,低镁血症,Meta分析

Abstract:

ObjectiveTo explore the relationship between PPIs and hypomagnesemia through systematic evaluation， and to provide the latest reference for its safe clinical application.MethodsThe Chinese and English search terms were set and published literatures about PPIs and hypomagnesemia were searched in PubMed， Web of Science， CNKI， CBM， Wan-fang and VIP databases. The studies were selected and the data were collected. The research quality evaluation tool provided by the NHLBI was selected to evaluate the quality of the included studies. The meta-analysis was performed on the collected data via RevMan5.3 software， and subgroup analysis was performed from multiple perspectives （patient's origin， country or regional distribution， and clinical study design）.ResultsAccording to the inclusion and exclusion criteria， a total of 16 studies about 26，149 patients were included， which were all of medium and high quality research findings assessed by quality assessment tool. In the included literature， 13 studies confirmed that PPIs was associated with hypomagnesemia， and 3 studies showed that PPIs was not associated with hypomagnesemia. The results of meta-analysis indicated that the risk of hypomagnesemia among PPIs users was 2.36 times higher than that in those non-users （OR= 2.36， 95%CI： 2.10 ~ 2.66，P< 0.000 01）. Subgroup analysis was conducted from the perspectives of patient’s origin （inpatient， outpatient and dialysis）， national or regional distribution （North America， Asia and Europe）， and clinical study design （cross-sectional， cohort and case-control）. The meta-analysis results were consistent with the risk of hypomagnesemia associated with PPIs.ConclusionThe use of PPIs is associated with an increased risk of hypomagnesemia， which is independent of user's origin， national or regional distribution of the study population， or clinical study design.

Key words:proton pump inhibitors,hypomagnesemia,Meta-analysis