betway必威登陆网址 (betway.com )学报››2022,Vol. 43››Issue (2): 148-155.DOI:10.3969/j.issn.2097-0005.2022.02.014

• 综述 •上一篇下一篇

miRNA对糖尿病脑病的临床意义

胡菲菲1(), 辛静昕1, 张新焕2()

  1. 1.betway必威登陆网址 (betway.com ),山东 济南 250117
    2.betway必威登陆网址 第二附属医院内分泌科,山东 泰安 271000
  • 收稿日期:2021-09-26出版日期:2022-02-25发布日期:2022-03-18
  • 通讯作者:张新焕
  • 作者简介:胡菲菲,硕士研究生,研究方向:内分泌,E-mail:724642385@qq.com第一联系人:
  • 基金资助:
    山东省自然科学基金高校、科研单位联合专项(ZR2017LH023);山东省高等学校科技计划(J17KA246)

The clinical significance of miRNA in diabetic encephalopathy

Feifei HU1(), Jingxin XIN1, Xinhuan ZHANG2()

  1. 1.Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China
    2.Department of Endocrinology, The second Affiliated Hospital of Shandong First Medical University, Taian 271000, China
  • Received:2021-09-26Online:2022-02-25Published:2022-03-18
  • Contact:Xinhuan ZHANG

摘要:

糖尿病作为一种复杂的代谢性疾病,可引起多个系统的并发症,其中糖尿病脑病的发生率近年来逐年上升,严重影响患者的生活质量。微小RNA(miRNA)作为非编码小RNA分子,在包括血清、血浆在内的许多生物体液中以无细胞循环形式稳定存在,并在组织稳定和疾病进展中发挥重要作用。由于某些miRNA的变化是细胞类型或组织特异性的,因此可以通过分析循环血液中的miRNA来识别组织功能障碍,此外miRNA还可作为某些疾病的治疗靶点。本综述就miRNA在糖尿病脑病的早期诊断及治疗方面做一综述。

关键词:微小RNA,糖尿病,糖尿病脑病

Abstract:

Diabetes as a complex metabolic disease, can cause complications of multiple systems. Incidence of diabetic encephalopathy has increased year by year in recent years, which has serious impact on the patient's quality of life. MiRNA as a small non-coding RNA molecules, stably exists in many biological fluids including serum and plasma in the form of cell-free circulation, and plays an important role in structure stability and progression of disease. Due to the fact that some changes in the miRNA are of cell type or tissue specificity, the analysis of circulating miRNA can be used to identify organizational dysfunction. In addition, the miRNA can be used as therapeutic targets in some diseases. This review summarizes miRNA in the early diagnosis and treatment of diabetic brain dysfunction.

Key words:miRNA,diabetes,diabetic encephalopathy